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THE TOXIC EFFECTS OF AMPHOTERICIN B IN MAN

By Charles W. Holeman and Hans Einstein

Abstract

Studies of 47 patients with intravenous amphotericin B revealed some impairment of renal function in all cases. Azotemia developed in 46 cases. Microscopic examination in eight cases showed damage to the distal renal tubule. Profound hypokalemia was recognized in two cases; and symptoms suggesting hypokalemia, which were generally ameliorated by potassium administration, were noted in most cases. It is postulated that the initial potassium loss is due to a “tubular leak” and that subsequent potassium depletion leads to further tubular damage

Topics: Articles
OAI identifier: oai:pubmedcentral.nih.gov:1515233
Provided by: PubMed Central
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