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Long-Term Exposure to Ambient Air Pollution and Incidence of Cerebrovascular Events : Results from 11 European Cohorts within the ESCAPE Project

By Massimo Stafoggia, Giulia Cesaroni, Annette Peters, Zorana J. Andersen, Chiara Badaloni, Rob Beelen, Barbara Caracciolo, Josef Cyrys, Ulf de Faire, Kees de Hoogh, Kirsten T. Eriksen, Laura Fratiglioni, Claudia Galassi, Bruna Gigante, Aki S. Havulinna, Frauke Hennig, Agneta Hilding, Gerard Hoek, Barbara Hoffmann, Danny Houthuijs, Michal Korek, Timo Lanki, Karin Leander, Patrik K. Magnusson, Christa Meisinger, Enrica Migliore, Kim Overvad, Claes-Goran Ostenson, Nancy L. Pedersen, Juha Pekkanen, Johanna Penell, Goran Pershagen, Noreen Pundt, Andrei Pyko, Ole Raaschou-Nielsen, Andrea Ranzi, Fulvio Ricceri, Carlotta Sacerdote, Wim J. R. Swart, Anu W. Turunen, Paolo Vineis, Christian Weimar, Gudrun Weinmayr, Kathrin Wolf, Bert Brunekreef and Francesco Forastiere

Abstract

BACKGROUND: Few studies have investigated effects of air pollution on the incidence of cerebrovascular events. OBJECTIVES: We assessed the association between long-term exposure to multiple air pollutants and the incidence of stroke in European cohorts. METHODS: Data from 11 cohorts were collected, and occurrence of a first stroke was evaluated. Individual air pollution exposures were predicted from land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE). The exposures were: PM2.5 [particulate matter (PM) = 2.5 m in diameter], coarse PM (PM between 2.5 and 10 m), PM10 (PM = 60 years of age (HR = 1.40, 95% CI: 1.05, 1.87), among neversmokers (HR = 1.74, 95% CI: 1.06, 2.88), and among participants with PM2.5 exposure <25 g/m(3) (HR = 1.33, 95% CI: 1.01, 1.77). CONCLUSIONS: We found suggestive evidence of an association between fine particles and incidence of cerebrovascular events in Europe, even at lower concentrations than set by the current air quality limit value

Topics: USE REGRESSION-MODELS, ACUTE ISCHEMIC-STROKE, PARTICULATE MATTER, PM2.5 ABSORBENCY, MORTALITY, AREAS, RISK, NO2, METAANALYSIS, PMCOARSE
Year: 2014
OAI identifier: oai:dspace.library.uu.nl:1874/305027
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