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Vitamin B6 and cancer: a multi-edged sword

By J. Mulder

Abstract

The bioactive vitamin B6 isoform pyridoxal phosphate (PLP) catalyses more than 140 enzymatic reactions in the human body. Vitamin B6 is reported to play a role in cancer. Carcinogenesis is a complicated multistep process characterized by metabolic alterations in tumor cells. Some pathways involved in cancer metabolism include enzymatic reactions that are PLP dependent. Besides, PLP is found to mediate one-carbon metabolism, oxidative stress, genomic stability, immune function and other processes suggested to play a role in carcinogenesis. As a co-factor for the enzymes cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL) and serine hydroxylmethyltransferase (SHMT) involved in one-carbon metabolism, vitamin B6 influences DNA synthesis, DNA methylation and oxidation. In a PLP deficient state altered one-carbon metabolism is hypothesised to enhance oxidative stress and genomic instability. Disturbed humoral and cellular immune responses are reported in vitamin B6 deficiency reversible upon vitamin B6 supplementation. Based on these findings a beneficial role in anti-cancer immune responses is hypothesised. In addition, vitamin B6 is reported to affect chemotherapy efficacy and chemotherapy mediated side effects. Beneficial effects of vitamin B6 are observed in the chemotherapeutic action of cisplatin and in the reduction of side-effects of several chemotherapeutic drug, however, contradicting results are observed. Here, we discuss the existing evidence for the role of vitamin B6 in cancer development and treatment

Topics: Vitamin B6, pyridoxal phosphate (PLP), carcinogenesis, one-carbon metabolism, oxidative stress, immunity, genomic stability
Year: 2014
OAI identifier: oai:dspace.library.uu.nl:1874/295339
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