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Plasmodium falciparum AMA1 Binds a Rhoptry Neck Protein Homologous to TgRON4, a Component of the Moving Junction in Toxoplasma gondii

By David L. Alexander, Shirin Arastu-Kapur, Jean-Francois Dubremetz and John C. Boothroyd

Abstract

Plasmodium falciparum apical membrane antigen 1 (PfAMA1) coimmunoprecipitates with the Plasmodium homologue of TgRON4, a secreted rhoptry neck protein of Toxoplasma gondii that migrates at the moving junction in association with TgAMA1 during invasion. PfRON4 also originates in the rhoptry necks, suggesting that this unusual collaboration of micronemes and rhoptries is a conserved feature of Apicomplexa

Topics: Articles
Publisher: American Society for Microbiology
OAI identifier: oai:pubmedcentral.nih.gov:1489286
Provided by: PubMed Central
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