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Memory consolidation from a place cell perspective

By S.E. Bosch


The hippocampus plays a key role in the encoding and consolidation of episodic memories. Recent evidence indicates that the hippocampal place cell network may be essential for these memory functions. Replay is the reactivation of previously stored hippocampal place cell ensembles representing behavioural trajectories and events. It occurs during sleep subsequent to encoding, but also during brief rest periods in the awake state. This phenomenon is initiated in the hippocampus, but its effects propagate throughout the brain. Sharp wave ripple-related hippocampal replay may underlie hippocampal-to-neocortical consolidation and retrieval of memories, although the exact mechanisms remain uncertain. Here, the evidence for the role of hippocampal replay in memory encoding, consolidation and retrieval will be reviewed

Topics: Hippocampus, episodic memory, consolidation, memory replay, sharp wave ripples
Year: 2011
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