Breast cancer is the second leading cause of cancer death in women, exceeded only by lung cancer. Breast optical imaging is novel method to image the breast with the use of near-infrared light. In optical breast imaging, two techniques can be distinguished, optical imaging without contrast agent, which only makes use of intrinsic tissue contrast, and optical imaging with a contrast agent, which uses fluorescent agents. In this review the basic concepts of optical breast imaging are described, clinical studies on optical imaging are summarized
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