Skip to main content
Article thumbnail
Location of Repository

The role of the Dendritic Cell in the immunobiology of Feline Infectious Peritonitis

By Anique van Berne


Feline Infectious Peritonitis (FIP) is a fatal disease in cats caused by a Coronavirus. During FIPv infection the T-cell population is depleted. This is seen in many other diseases, such as measles and AIDS. In these two diseases, the Dendritic Cell (DC) has been shown to play a role in T-cell depletion. This study endeavours to prove if such a mechanism exists in FIP. \ud In order to investigate permissiveness of DCs for FIPv, a growth curve was produced. This growth curve showed prolonged viral reproduction to intermediate titres. As T-cell depletion during FIPv infection occurs at least partly through apoptosis, a TUNEL assay was used to evaluate this. FACS analysis of infected and non-infected co-cultures of DCs with Thymocytes revealed no difference in apoptosis levels. These data suggest that T-cell depletion during FIPv infection does not occur through apoptosis initiated by FIPv-infected DCs

Topics: Diergeneeskunde, Dendritic Cell, FIP, Thymocyte, apoptosis
Year: 2008
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.