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Regulation of initiation of DNA synthesis in relation to mitosis in cultured hepatoma cells

By R. van Wijk, G. Zoutewelle and K.W. van de Poll


The commitment of Reuber H 35 hepatoma cells to DNA synthesis was studied by exposing cells which were synchronized by serum depletion, to serum. It is shown that the period of commitment is 6–8 hr, independent of the length of the G1 phase. It can even occur during the G2 period of the previous cell cycle

Topics: Biologie
Year: 1979
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