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Frequency-dependent effects of the pyrethroid insecticide decamethrin in frog myelinated nerve fibres

By H.P.M. Vijverberg and J. van den Bercken


The pyrethroid insectide decamethrin (10−6M) caused a frequency-dependent depression of the action potential in frog myelinated nerve fibres which was associated with a progressive membrane depolarisation brought about by summation of depolarising after-potentials. Voltage clamp experiments with single nodes of Ranvier showed that this afterpotential was most probably due to a long-lasting prolongation of the transient increase in sodium permeability of the membrane. The results indicate that decamethrin, like the other pyrethroids, specifically affects the sodium channels of the nerve membrane

Topics: Diergeneeskunde, depolarising after-potential, frequency-dependent depression, frog node of Ranvier, decamethrin, prolongation of sodium permeability, pyrethroids
Year: 1979
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