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Protein-stimulated exchange of phosphatidylcholine between intact erythrocytes and various membrane systems

By G. van Meer, L.G. Lange, J.A.F. op den Kamp and L.L.M. van Deenen


Phosphatidylcholine specific exchange protein from beef liver was found to catalyze the exchange of phosphatidylcholine between intact rat and human erythrocytes and various artificial membranes. Both multilamellar liposomes and single bilayer vesicles prepared from egg lecithin, cholesterol and phosphatidic acid (46:50:4, mol/mol) appeared to be effective phospholipid donor systems. Some merits and disadvantages of the various donor systems are discussed

Topics: Scheikunde, cholesterol, liposome, phosphatidylcholine, phospholipid exchange protein
Year: 1980
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