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Neuroleptic-like activity of peptides related to [DES-TYR1] γ-endorphin: Structure activity studies

By D. de Wied, J.M. van Ree and H.M. Greven


The potency of various fragments of γ-endorphin (β-LPH61–77) was compared on their ability to facilitate extinction of pole-jumping avoidance behavior and their effects in two “grip tests” used as measures of neuroleptic-like activity. It appeared that β-LPH66–77 is the shortest sequence which shows potencies in the three tests comparable to that of DTγE (β-LPH62–77). The activity of β-LPH67–77 was less. It is proposed that β-LPH66–77 rather than DTγE represents an endogenous neuroleptic-like neuropeptide which may play a key role in psychopathology

Topics: Geneeskunde
Year: 1980
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