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Immunity to Babesia in mice II. Cross protection between various Babesia and Plasmodium species and its relevance to the nature of Babesia immunity

By H. Kuil, D. Zivkovic, J.E. Speksnijder and W. Seinen


Mice immunized against B.rodhaini by means of a drug-controlled\ud infection were subsequently resistant to infection with B.microti\ud and B.ratti. In the reciprocal experiments the protection against\ud B.rodhaini was less effective. B.rodhaini immunized mice were also\ud considerably protected against P.vinckei infection, whereas protection\ud against P.berqhei did not occur. Antibody determinations\ud indicated that the heterologous protection cannot be explained by\ud the occurrence of cross-reacting antibodies. Because of similarity\ud with the non-specific suppression of babesiosis in BCG-infected\ud mice, the same effector mechanism is postulated to explain the\ud infection-induced homologous and heterologous protection. Unlike\ud non-specifically induced protection, the induction of acquired\ud resistance by means of a drug-controlled B.rodhaini infection is\ud thymus-dependent

Topics: Diergeneeskunde
Year: 1984
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