Skip to main content
Article thumbnail
Location of Repository

Hippocampal kindling: corticosterone modulation of induced seizures

By E.R. de Kloet, G.A. Cottrell, C. Nyakas and B. Bohus

Abstract

The effect of adrenalectomy (ADX) and corticosterone replacement was studied on seizures induced by hippocampal kindling. A complex series of changes occurred in after-discharge (AD) and behavioural depression (BD) during the immediate hours after ADX, culminating at day 1 in markedly decreased AD and BD, which returned to normal over the next several days. These changes were normalized after replacement of the ADX group with low doses of corticosterone. It is concluded that the expression and maintenance of hippocampal kindled seizures is under short-term control of corticosterone

Topics: Geneeskunde, kindling -- hippocampus -- adrenalectomy -- corticosterone -- behavioral depression -- after-discharge
Year: 1984
OAI identifier: oai:dspace.library.uu.nl:1874/23855
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dspace.library.uu.nl:80... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.