The N-myc oncogene was first identified as an amplified DNA element\ud with homology to c-myc in human neuroblastoma. Since this initial\ud observation, amplification of N-myc has also been observed in other types\ud of human cancer, predominantly in retinoblastoma and small cell lung\ud cancer. The apparent role of the N-myc oncogene in neuroblastoma\ud oncogenesis is unusual in that amplification of N-myc is hardy ever observed\ud in primary non-metastatic neuoblastoma. Rather, amplification of\ud N-myc has been found predominantly in advanced, widely metastatic\ud neuroblastoma. This close association between N-myc amplification\ud and metastatic ability suggests that a relationship exists between these\ud two phenomena, namely that N-myc over-expression is responsible for\ud the increased metastatic ability of the N-myc-amplified tumor cells
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