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Comparison of breast cancer mucin (BCM) and CA 15-3 in human breast cancer

By M.B. Garcia, M.A. Blankenstein, E. van der Wall, J.W.R. Nortier, J.H. Schornagel and J.H.H. Thijssen

Abstract

The Breast Cancer Mucin (BCM) enzyme immunoassay utilizes two monoclonal antibodies (Mab), M85/34 and F36/22, for the identification of a mucin-like glycoprotein in serum of breast cancer patients. We have\ud compared BCM with CA 15-3, another member of the human mammary epithelial antigen family.\ud Serum BCM was evaluated in 151 and CA 15-3 in 134 patients with breast cancer, in 30 normal controls, in 9 pregnant women, and in 13 cancer patients (non-breast). Neither the normal controls nor the pregnant women had BCM levels > 25 U/ml. In contrast, 87 of 115 patients (75%) with metastatic breast cancer had BCM levels > 25 U/ml. All control persons had CA 15-3 levels < 25 U/ml, but 2 out of 9 pregnant women (22%) had levels > 25 U/ml. Seventy-four out of 97 patients (76%) with metastatic breast cancer had CA\ud 15-3 levels > 25 U/ml. A statistically significant correlation was found between BCM and CA 15-3 in the breast cancer patient\ud group (r = 0.883, p < 0.001, n = 134) and in the normal control group (r = 0.743, p < 0.001, n = 30). BCM and CA 15.3 both showed no correlation with CEA in breast cancer patients (r = 0.060, n = 81; and r = 0.146, n = 78, respectively). BCM had a range of sensitivity similar to that of the CA 15-3 RIA. Our results suggest that BCM may be a useful new marker for monitoring the clinical course of patients with breast cancer. Furthermore, in the evaluation of breast cancer patients, marker pands depending on disease stage may be a better choice than any single parameter in the evaluation of breast cancer patients

Topics: Geneeskunde, BCM, breast cancer, CA 15-3, CEA, mucin,, tumour markers
Year: 1990
OAI identifier: oai:dspace.library.uu.nl:1874/21584
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