Skip to main content
Article thumbnail
Location of Repository

Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector

By R.A. Bernards, A. Destree, S. McKenzie, E. Gordon, R.A. Weinberg and D. Panicali

Abstract

We have constructed a vaccinia virus recombinant that expresses the extracellular domain of the rat neu oncogene-encoded protein, a 185-kDa transmembrane glycoprotein termed p185. Strain NFS mice immunized with this recombinant virus developed a strong antibody response against the neu oncogene product and were fully protected against subsequent tumor challenge with neu-transformed NIH 3T3 cells. No tumor immunoprotection was found when recombinant virus-immunized mice were challenged with Ha-ras-transformed NIH 3T3 cells. These data indicate that immunization with a single oncogene-encoded antigen can fully and specifically protect animals against tumor cells bearing this antigen

Topics: Biologie
Year: 1987
OAI identifier: oai:dspace.library.uu.nl:1874/15034
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dspace.library.uu.nl:80... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.