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Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector

By R.A. Bernards, A. Destree, S. McKenzie, E. Gordon, R.A. Weinberg and D. Panicali


We have constructed a vaccinia virus recombinant that expresses the extracellular domain of the rat neu oncogene-encoded protein, a 185-kDa transmembrane glycoprotein termed p185. Strain NFS mice immunized with this recombinant virus developed a strong antibody response against the neu oncogene product and were fully protected against subsequent tumor challenge with neu-transformed NIH 3T3 cells. No tumor immunoprotection was found when recombinant virus-immunized mice were challenged with Ha-ras-transformed NIH 3T3 cells. These data indicate that immunization with a single oncogene-encoded antigen can fully and specifically protect animals against tumor cells bearing this antigen

Topics: Biologie
Year: 1987
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