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The activity of etoposide (VP16) in combination chemotherapy against human bladder cancer cells in vitro

By 智任 服部, 三洋 佐藤, 保典 寺島, 泰司 西村 and 成太 秋元


The activity of Etoposide (VP16) in combination chemotherapy against four human transitional cell carcinoma cell lines of bladder (TCCaB) was determined by in vitro colony formation assay. Four anti-tumor agents (methotrexate: MTX, vinblastine: VBL, adriamycin: ADM, cisplatin: DDP) were used for combination chemotherapy with VP16. The ADM + VP16 combination exhibited a strong synergistic antitumor effect against the human TCCaBs compared with other combinations in this study. The combination chemotherapy of ADM + VP16 may be useful as a new chemotherapeutic regimen for advanced bladder cancer

Topics: Bladder cancer, Etoposide (VP16), Chemosensitivity assay, Combination chemotherapy, 494.9
Publisher: 泌尿器科紀要刊行会
Year: 1991
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