THE EFFECT ON EXTRAVASCULAR PULMONARY FLUID BY LOADING HYPOXIA AND DECREASING PULMONARY VASCULAR BED

Abstract

この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。肺循環の変化が血管外肺水分量に及ぼす影響を調べるために, 雑種成犬を用い, 左肺全摘と右上葉切除に加えて, 12%O_2, N_2バランスの低酸素負荷を行なった。これを, Diltiazem投与群と非投与群とに分け, それぞれの残存肺の血管外肺水分量を測定した。予備実験として, 左肺全摘に加えて, 10∿12%O_2, N_2バランスの低酸素負荷を行ない, 残存肺の血管外肺水分量を測定した。各群とも, 左房圧, 心拍出量, 体動脈圧等に差を認めなかった。血管外肺水分量は, 肺動脈圧が高い程, また肺血流量が多い程高値を示した。Ca拮抗剤であるDiltiazemは, 低酸素性肺血管収縮反応を抑制し, 肺高血圧症を軽減させた。Hypoxic loading of 12%O_2, N_2 balans was performed in open-chest mongrel dogs with left pneunectomy and right upper lobectomy to examine the effect of change of pulmonary circulation on extravascular pulmonary fluid. Subsequently extravascular pulmonary fluid in residual lung was measured respectively in control group and Diltiazem group. In addition to left pneumonectomy, hypoxic loading was performed in preliminary experiment and extravascular pulmonary fluid in residual lung was measured to result in no significant difference of left atrial pressure, cardiac out put and systemic blood pressure in both groups. In the higher pulmonary artery pressure and the more pulmonary blood flow, extravascular pulmonary fluid demonstrated the higher value. It was concluded that Diltiazem, Ca antagonist, supressed hypoxic pulmonary vasoconstriction and reduced pulmonary hypertantion