Article thumbnail
Location of Repository

Overdiagnosis and overtreatment of breast cancer: Rates of ductal carcinoma in situ: a US perspective

By Anjali S Kumar, Vinona Bhatia and I Craig Henderson


The incidence of breast ductal carcinoma in situ (DCIS) in the USA exceeds that of other countries. This cannot be explained entirely by the frequency of mammographic screening in the USA and may result from differences in the interpretation of mammograms and/or the frequency with which biopsies are obtained. Although the percentage of DCIS patients treated with mastectomy has decreased, the absolute number is unchanged and the use of lumpectomy with whole-breast radiotherapy has increased in inverse proportion to the decrease in mastectomy. Treatment of DCIS with tamoxifen is still limited

Topics: Review
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (1980). Age-specific incidence rates of in situ breast carcinomas by histologic type,
  2. (2003). Breast Screening Programme,
  3. (2005). Cancer Trends in England and Wales, Incidence Data to 2002. National Cancer Intelligence Centre, Office for National Statistics;
  4. (1999). Colburn WJ: The influence of margin width on local control of ductal carcinoma in situ of the breast.
  5. (2001). Committee on Technologies for the Early Detection of Breast Cancer, Nass SJ, Henderson IC, Lashof JC (eds): Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer.
  6. conference report.
  7. (1975). EJ, Edwards BK (eds): SEER Cancer Statistics Review,
  8. (2003). et al.: Comparison of screening mammography in the United States and the United Kingdom. JAMA
  9. (2002). et al.: Detection of ductal carcinoma in situ in women undergoing screening mammography.
  10. (1993). et al.: Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer.
  11. (1999). et al.: Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial. Lancet
  12. (1997). La Vecchia C: Trends of in situ carcinoma of the breast in Vaud, Switzerland.
  13. (2000). Mortality among women with ductal carcinoma in situ of the breast in the population-based surveillance, epidemiology and end results program. Arch Intern Med
  14. (2004). Physician recommendations regarding tamoxifen and patient utilization of tamoxifen after surgery for ductal carcinoma in situ. Cancer
  15. (2003). Ransohoff DF: International variation in screening mammography interpretations in community-based programs.
  16. (2002). Services Task Force: Screening for breast cancer: recommendations and rationale. Ann Intern Med
  17. (2004). Taghian A: The management of ductal carcinoma in situ in North America and Europe. Results of a survey. Cancer
  18. (2004). TM: Trends in the treatment of ductal carcinoma in situ of the breast.
  19. (1999). Wolmark N: Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight-year update of Protocol B-17: intraductal carcinoma. Cancer

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.