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Characterization of the impact of magnesium stearate lubrication on the tableting properties of chitin-Mg silicate as a superdisintegrating binder when compared to Avicel (R) 200

By Iyad Rashid, Nidal Daraghmeh, Mayyas Al-Remawi, Stephen A. Leharne, Babur Z. Chowdhry and Adnan Badwan


The influence of the lubricant magnesium stearate (MgSt) on the powder and tablet properties of chitin-Mg silicate coprecipitate was examined and compared with lubricated Avicel (R) 200 and Avicel-Mg silicate coprecipitate. Crushing strength and disintegration time studies were conducted in order to evaluate tablet properties at different compression pressures. Lubrication of chitin-Mg silicate powder with MgSt was evaluated using a high speed rotary tablet press. The compactability and disintegration time of chitin-Mg silicate are unaffected by the possible deleterious action of up to 2% (w/w) MgSt. The deleterious effect of MgSt on Avicel (R) 200 compaction was found to be minimized when magnesium silicate was coprecipitated onto Avicel (R) 200. Lubrication of chitin-Mg silicate with MgSt does not enhance particle agglomeration, whereas the opposite is the case for Avicel (R) 200; the foregoing was ascertained by measurements of the fixed bulk density, constant powder porosity using Kawakita analysis and by the absence of variation in particle size distribution in the presence of up to 5% (w/w) MgSt. In the case of chitin-Mg silicate tablets the ejection force was greatly reduced at a compression speed of 150,000 tablet/h at a MgSt concentration of 0.5% (w/w). The physical properties and drug dissolution profile of ibuprofen tablets were found to be unaffected when chitin-Mg silicate was lubricated up to 5% (w/w) with MgSt. Optimal drug dissolution was attained for gemfibrozil tablets using 3% (w/w) MgSt when compared to a reference (Lopid tablets)

Topics: QD
Publisher: Elsevier
Year: 2010
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