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Rat brain amines, blood histamine and glucose levels in relationship to circadian changes in sleep induced by pentobarbitone sodium

By Alexander H. Friedman and Charles A. Walker


1. The circadian patterns for onset and duration of sleep after the administration of a constant dose of pentobarbitone sodium have been measured in rats adapted to and maintained under a fixed illumination cycle. The relationship of these patterns to others for rectal temperature and motor activity as well as for noradrenaline (NA), 5-hydroxytryptamine (5-HT) and histamine in mid-brain and caudate nucleus, and histamine and glucose in blood serum, has been examined

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