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IMGT/LIGM-DB, the IMGT® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences

By Véronique Giudicelli, Patrice Duroux, Chantal Ginestoux, Géraldine Folch, Joumana Jabado-Michaloud, Denys Chaume and Marie-Paule Lefranc

Abstract

IMGT/LIGM-DB is the IMGT® comprehensive database of immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences from human and other vertebrate species. It was created in 1989 by LIGM, Montpellier, France and is the oldest and the largest database of IMGT®. IMGT/LIGM-DB includes all germline (non-rearranged) and rearranged IG and TR genomic DNA (gDNA) and complementary DNA (cDNA) sequences published in generalist databases. IMGT/LIGM-DB allows searches from the Web interface according to biological and immunogenetic criteria through five distinct modules depending on the user interest. For a given entry, nine types of display are available including the IMGT flat file, the translation of the coding regions and the analysis by the IMGT/V-QUEST tool. IMGT/LIGM-DB distributes expertly annotated sequences. The annotations hugely enhance the quality and the accuracy of the distributed detailed information. They include the sequence identification, the gene and allele classification, the constitutive and specific motif description, the codon and amino acid numbering, and the sequence obtaining information, according to the main concepts of IMGT-ONTOLOGY. They represent the main source of IG and TR gene and allele knowledge stored in IMGT/GENE-DB and in the IMGT reference directory. IMGT/LIGM-DB is freely available at

Topics: Article
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:1347451
Provided by: PubMed Central
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    1. Giudicelli,V.,Protat,C.andLefranc,M.-P.(2003)The IMGTstrategyfor the automatic annotation of IG and TR cDNA sequences: IMGT/ Automat.
    2. (2005). IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains.
    3. (2003). IMGT unique numberingforimmunoglobulinandTcellreceptorvariabledomainsand Ig superfamily V-like domains.
    4. (2005). IMGT-Choreography for Immunogenetics and Immunoinformatics.
    5. (1999). IMGT, the international ImMunoGeneTics database.
    6. (2004). IMGT, the international ImMunoGenetics information system ,
    7. (2005). IMGT, the international ImMunoGeneTics information system .
    8. (2005). IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes.
    9. (2004). IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs.
    10. (2004). IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis.
    11. (2005). Immunogenetics sequence annotation: the strategy of IMGT based on IMGT-ONTOLOGY.
    12. (1995). LIGM-DB/IMGT: an integrated database of Ig and TcR, part of the immunogenetics database.
    13. (1999). Ontology for immunogenetics: the IMGT-ONTOLOGY.
    14. Scaviner,D., Thouvenin,V.etal.(2004)IMGT-ONTOLOGYforimmunogeneticsand immunoinformatics.
    15. (2005). The EMBL nucleotide sequence database.
    16. (1999). The IMGT unique numbering for Immunoglobulins, T cell receptors and Ig-like domains.
    17. (2001). The Immunoglobulin FactsBook.
    18. (2001). The T cell receptor FactsBook.
    19. (1997). Unique database numbering system for immunogenetic analysis.

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