Inhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectants

Abstract

We characterized the effects of selective Cox-2 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of antisense Cox-2 cDNA (Cox-2-AS) or pharmacological inhibition by selective cox-2 inhibitor (NS398). The conditioned media obtained from SGC7901 treated with Cox-2-AS or NS398 suppressed the proliferation, migration and tube formation of human umbilical vein endothelial cells. Moreover, both treatments inhibited in vivo angiogenesis. These inhibitions could be partially reversed by the addition of PGE2. Our findings support that selective inhibition of Cox-2 alone plays an instrumental role on gastric cancer associated angiogenesis. © 2004 Elsevier Ireland Ltd. All rights reserved.link_to_subscribed_fulltex

Similar works

Full text

thumbnail-image

HKU Scholars Hub

redirect
Last time updated on 01/06/2016

This paper was published in HKU Scholars Hub.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.