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Plasma-sprayed calcium phosphate particles with high bioactivity and their use in bioactive scaffolds

By J Weng, M Wang and J Chen

Abstract

Highly crystalline feedstock hydroxyapatite (HA) particles with irregular shapes were spheroidized by plasma spraying them onto the surface of ice blocks or into water. The spherical Ca-P particles thus produced contained various amounts of the amorphous phase which were controlled by the stand-off distance between the spray nozzle and the surface of ice blocks or water. The smooth surface morphology without cracks of spherical Ca-P particles indicated that there were very low thermal stresses in these particles. Plasma-sprayed Ca-P particles were highly bioactive due to their amorphous component and hence quickly induced the formation of bone-like apatite on their surfaces after they were immersed in an acellular simulated body fluid at 36.5°C. Bone-like apatite nucleated on dissolved surface (due to the amorphous phase) of individual Ca-P particles and grew to coalesce between neighboring Ca-P particles thus forming an integrated apatite plate. Bioactive and biodegradable composite scaffolds were produced by incorporating plasma-sprayed Ca-P particles into a degradable polymer. In vitro experiments showed that plasma-sprayed Ca-P particles enhanced the formation of bone-like apatite on the pore surface of Ca-P/PLLA composite scaffolds. © 2002 Elsevier Science Ltd. All rights reserved.link_to_subscribed_fulltex

Topics: Bone Substitutes - Chemistry, Biocompatible Materials, Calcium Phosphates - Chemistry, Durapatite - Chemistry, Lactic Acid - Chemistry, Microscopy, Electron, Scanning, Models, Chemical, Polymers - Chemistry, X-Ray Diffraction
Publisher: 'Elsevier BV'
Year: 2002
DOI identifier: 10.1016/S0142-9612(01)00393-3
OAI identifier: oai:hub.hku.hk:10722/156624
Provided by: HKU Scholars Hub
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