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Pattern of cerebral atherosclerosis in Hong Kong Chinese: Severity in intracranial and extracranial vessels

By IJ Lauder, THK Ng, Suet Yi Leung, FCS Ho and Siu Tsan Yuen

Abstract

Background and Purpose: The clinical pattern of stroke and the angiographic distribution of cerebral atherosclerosis in Chinese are different from those in Caucasians. Pathological data from autopsy studies are lacking. Methods: The intracranial and extracranial arteries supplying the brains of 114 consecutive Chinese patients undergoing autopsy in a regional general hospital were examined by computer-assisted morphometric analysis under a microscope as well as by macroscopic grading for atherosclerotic narrowing. The severity was correlated with various atherosclerosis-related factors. Results: Atherosclerosis of the intracranial cerebral vessels was more severe than that of the extracranial vessels. The distal branches of the intracranial vessels were also commonly involved. Hypertension and diabetes mellitus were identified as factors associated only with intracranial atherosclerosis (p<0.001), whereas ischemic heart disease was associated with atherosclerosis in both the intracranial (p<0.001) and extracranial (p=0.012) vessels. Smoking was associated with narrowing of the extracranial vessels only (p=0.0054). Conclusions: Compared with figures from Caucasian and Japanese populations, the extent of intracranial atherosclerosis is much more severe in Hong Kong Chinese, whereas atherosclerotic narrowing of the extracranial carotid artery is less severe in Hong Kong Chinese than in Caucasians.link_to_subscribed_fulltex

Topics: Adolescent, Adult, Aged, Aging, Arteriosclerosis - Complications - Epidemiology - Pathology, Autopsy, Carotid Arteries - Pathology, Cerebral Arteries - Pathology, Cerebrovascular Disorders - Epidemiology - Etiology - Pathology, Child, Child, Preschool, China - Ethnology, Diabetes Complications, Female, Hong Kong, Humans, Hypertension - Complications, Infant, Male, Middle Aged, Myocardial Ischemia - Complications, Smoking - Adverse Effects
Publisher: 'United States Sports Academy'
Year: 1993
DOI identifier: 10.1161/01.str.24.6.779
OAI identifier: oai:hub.hku.hk:10722/147957
Provided by: HKU Scholars Hub
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