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The value of tumor markers in a mixed tumor, mucinous and neuroendocrine carcinoma of the ovary

By HK Ma, HYS Ngan, SYW Chan, LC Wong and RJ Collins


Serum CA 125 is frequently used to monitor the treatment response and to detect early recurrence during the follow-up of patients who have epithelial ovarian tumors. In this report, the level of serum CA 125 and urinary 5-hydroxyindole acetic acid of a patient with a carcinoid tumor which occurred in association with a mucinous adenocarcinoma of the ovary is described. The level of serum CA 125 decreased despite the presence of a clinically progressive tumor. There was a rise of the 5-hydroxyindole acetic acid level 16 weeks before pelvic recurrence was detected clinically. This indicates that it was the neuroendocrine component, and not the mucinous component of the tumor, that was not responsive to the chemotherapy. The problem of using tumor markers to monitor patients with mixed tumors is discussed.link_to_subscribed_fulltex

Topics: Endocrine System Diseases - Drug Therapy - Pathology, Adenocarcinoma, Mucinous - Drug Therapy - Pathology, Adult, Antineoplastic Combined Chemotherapy Protocols - Therapeutic Use, Cisplatin - Administration & Dosage, Cyclophosphamide - Administration & Dosage, Female, Humans, Neoplasms, Germ Cell And Embryonal - Drug Therapy - Pathology, Nervous System Neoplasms - Drug Therapy - Pathology, Ovarian Neoplasms - Drug Therapy - Pathology, Staining And Labeling, Tumor Markers, Biological - Analysis
Publisher: 'United States Sports Academy'
Year: 1989
DOI identifier: 10.1016/0090-8258(89)90059-0
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Provided by: HKU Scholars Hub
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