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Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination

By F Zeng, H Chen, N Xia, J Zhang, S Huang, WL Wu, SY Lau, K Yang, Q Zheng and Y Chen

Abstract

A serological survey for antibodies to influenza viruses was performed in China on a group of people without a history of influenza vaccination. Using the haemagglutination inhibition (HI) assay, we found seropositivity rates for seasonal H3N2 to be significantly higher than those for seasonal H1N1. Samples positive for antibodies to the pandemic (H1N1) 2009 virus increased from 0.6% pre-outbreak to 4.5% (p <0.01) at 1 year post-outbreak. Interestingly, HI and neutralization tests showed that 1.4% of people in the group have antibodies recognizing H9N2 avian influenza viruses, suggesting that infection with this subtype may be more common than previously thought.link_to_OA_fulltex

Topics: Influenza, Human - epidemiology - immunology - virology, Influenza A virus - classification - immunology, Influenza A Virus, H3N2 Subtype - immunology, Influenza A Virus, H1N1 Subtype - immunology, Antibodies, Viral - blood
Publisher: 'Wiley'
Year: 2011
DOI identifier: 10.1111/j.1469-0691.2011.03538.x
OAI identifier: oai:hub.hku.hk:10722/142416
Provided by: HKU Scholars Hub
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