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Outbreaks in Distinct Regions Due to a Single Klebsiella pneumoniae Clone Carrying a bla(VIM-1) Metallo-β-Lactamase Gene

By Alexandros Ikonomidis, Despina Tokatlidou, Ioulia Kristo, Danai Sofianou, Athanassios Tsakris, Paraskevi Mantzana, Spyros Pournaras and Antonios N. Maniatis


From December 2004 to March 2005, 27 Klebsiella pneumoniae clinical isolates that were positive by the imipenem-EDTA double-disk synergy test and that exhibited a single macrorestriction pattern were recovered in two distinct Greek hospitals. The isolates carried a transferable bla(VIM-1) metallo-β-lactamase gene in a class 1 integron. Reverse transcriptase PCR showed that the gene was similarly expressed in low- and high-level carbapenem-resistant isolates, indicating the existence of additional resistance mechanisms. The clonal spread of VIM-1-producing K. pneumoniae strains in distinct regions where up to now bla(VIM-2) and bla(VIM-4) alleles were common is worrisome

Topics: Epidemiology
Publisher: American Society for Microbiology
Year: 2005
DOI identifier: 10.1128/JCM.43.10.5344-5347.2005
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Provided by: PubMed Central
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