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Acute exposure to environmental tobacco smoke and heart rate variability.

By C A Pope, D J Eatough, D R Gold, Y Pang, K R Nielsen, P Nath, R L Verrier and R E Kanner

Abstract

Environmental tobacco smoke (ETS) has been associated with cardiovascular mortality. Pathophysiologic pathways leading from ETS exposure to cardiopulmonary disease are still being explored. Reduced cardiac autonomic function, as measured by heart rate variability (HRV), has been associated with cardiac vulnerability and may represent an important pathophysiologic mechanism linking ETS and risk of cardiac mortality. In this study we evaluated acute ETS exposure in a commercial airport with changes in HRV in 16 adult nonsmokers. We conducted ambulatory electrocardiographic (ECG) monitoring for 8-hr periods while participants alternated 2 hr in nonsmoking and smoking areas. Nicotine and respirable suspended particle concentrations and participants' blood oxygen saturation were also monitored. We calculated time and frequency domain measures of HRV for periods in and out of the smoking area, and we evaluated associations with ETS using comparative statistics and regression modeling. ETS exposure was negatively associated with all measures of HRV. During exposure periods, we observed an average decrement of approximately 12% in the standard deviation of all normal-to-normal heart beat intervals (an estimate of overall HRV). ETS exposures were not associated with mean heart rate or blood oxygen saturation. Altered cardiac autonomic function, assessed by decrements in HRV, is associated with acute exposure to ETS and may be part of the pathophysiologic mechanisms linking ETS exposure and increased cardiac vulnerability

Topics: Research Article
Year: 2001
OAI identifier: oai:pubmedcentral.nih.gov:1240375
Provided by: PubMed Central

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Citations

  1. (1999). Air pollution and hospital admissions for heart disease in eight U.S. counties.
  2. (2000). Ambient pollution and heart rate variability.
  3. (1995). Associations between ambient particulate sulfate and admissions to Ontario hospitals for cardiac and respiratory diseases.
  4. (1998). Autonomic effects of nicotine patch administration in habitual cigarette smokers: a double-blind, placebo-controlled study using spectral analysis of RR interval and systolic arterial pressure variabilities.
  5. (1997). Beta blockade, ventricular arrhythmias, and sudden cardiac death.
  6. (1991). C Language algorithms for digital signal processing. Englewood Cliffs,
  7. (1999). Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Environ Health Perspect
  8. (1993). Econometric Analysis. 2nd ed.
  9. (1996). Effect of 21 mg transdermal nicotine patches and smoking cessation on heart rate variability.
  10. (1996). Environmental tobacco smoke and coronary heart disease in
  11. (1999). Environmental tobacco smoke and measures of subclinical vascular disease. Environ Health Perspect 107(suppl 6):837–840
  12. (1997). Environmental tobacco smoke exposure and ischemic heart disease: an evaluation of the evidence.
  13. Environmental tobacco smoke in commercial aircraft. Atmos Environ
  14. (1999). Epidemiologic studies of fatal and nonfatal cardiovascular disease and ETS exposure from spousal smoking. Environ Health Perspect 107(suppl 6):841–846
  15. (1999). Epidemiology of particle effects. In: Air Pollution and Health
  16. (1999). First steps toward understanding the pathophysiologic link between air pollution and cardiac mortality.
  17. (1999). Heart rate variability associated with particulate air pollution.
  18. (1998). Heart rate variability during the first month of smoking cessation.
  19. (1988). Inc. SAS/ETS User’s Guide, Version 6.
  20. (2000). Mechanisms of morbidity and mortality from exposure to ambient air particles.
  21. (1999). Occupational exposure to environmental tobacco smoke and health risk assessment. Environ Health Perspect 107(suppl 6):829–835
  22. (1999). Oxygen saturation, pulse rate, and particulate air pollution: a daily time-series panel study.
  23. (1995). Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults.
  24. (1995). Passive smoking and heart disease: mechanisms and risk.
  25. (1999). Passive smoking and risk of coronary heart disease–a meta-analysis of epidemiologic studies.
  26. (1994). Passive smoking as a cause of heart disease.
  27. (1998). Prospective study of heart rate variability and mortality in chronic heart failure.
  28. (1999). Risk assessment for heart disease and workplace ETS exposure among nonsmokers. Environ Health Perspect 107(suppl 6):859–863
  29. Spectral analysis of the heart rate variability signal.
  30. (1993). Speizer FE. An association between air pollution and mortality in six U.S. cities.
  31. (1996). Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use.
  32. (1990). The determination of nicotine and cotinine by ion pair reversed-phase chromatography.
  33. (1997). Trillium3000 Holter System Operator Manual. East Syracuse,
  34. (1999). Why is environmental tobacco smoke more strongly associated with coronary heart disease than expected? A review of potential biases and experimental data. Environ Health Perspect 107(suppl 6):853–858
  35. (1999). Workplace exposure to passive smoking and risk of cardiovascular disease: summary of epidemiologic studies. Environ Health Perspect 107(suppl 6):847–851

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