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In Vitro Synergy Testing of Anidulafungin with Itraconazole, Voriconazole, and Amphotericin B against Aspergillus spp. and Fusarium spp.

By Annie Philip, Zekaver Odabasi, Jose Rodriguez, Victor L. Paetznick, Enuo Chen, John H. Rex and Luis Ostrosky-Zeichner


The in vitro interactions of anidulafungin with itraconazole, voriconazole, and amphotericin B were evaluated by using the checkerboard method. For Aspergillus spp., anidulafungin with amphotericin B showed indifference for 16/26 isolates, while anidulafungin with either azole showed a synergy trend for 18/26 isolates. All drug combinations showed indifference for 7/7 Fusarium sp. isolates

Topics: Susceptibility
Publisher: American Society for Microbiology
Year: 2005
DOI identifier: 10.1128/AAC.49.8.3572-3574.2005
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Provided by: PubMed Central
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