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Iron-binding fragments from the N-terminal and C-terminal regions of human lactoferrin.

By J M Bluard-Deconinck, J Williams, R W Evans, J van Snick, P A Osinski and P L Masson


Digestion of lactoferrin with pepsin at pH3.0 gave an iron-binding half-molecule that represents the C-terminal part of the native protein. Tryptic or chymotryptic digestion of 30%-iron-saturated lactoferrin yielded the N- and C-terminal half molecules, which could be separated by DEAE-Sephadex chromatography. The N- and C-terminal fragments did not show any immunological cross-reaction. The carbohydrate of lactoferrin was distributed equally between the two fragments

Topics: Research Article
Year: 1978
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Provided by: PubMed Central
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