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The metabolism of shikimate in the rat.

By D Brewster, R S Jones and D V Parke

Abstract

In the rat, shikimate was metabolized and excreted as hippurate, hexahydrohippurate, 3,4,5,6-tetrahydrohippurate, t-3,t-4-dihydroxycyclohexane-r-1-carboxylate and c-3,t-4-dihydroxycyclophexane-r-1-carboxylate, conjugates of catechol and CO2. The metabolism was entirely dependent on various initial microbial transformations in the gut, metabolite formation being suppressed in animals pretreated with antibiotics. Shikimate was not metabolized by mammalian tissues, and products of microbial metabolism were excreted either unchanged or after further biotransformation in the animal tissues

Topics: Research Article
Year: 1978
DOI identifier: 10.1042/bj1700257
OAI identifier: oai:pubmedcentral.nih.gov:1183892
Provided by: PubMed Central
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