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Transmembrane migration ('flip-flop') of cholesterol in erythrocyte membranes.

By C Kirby and C Green


After exchange with [14C]cholesterol-labelled plasma lipoproteins for 0.5-4h, erythrocytes were extracted with bile-salt solutions. The extracted cholesterol (mainly from the outside of the erythrocyte membrane) had the same specific radioactivity as the residual sterol. Thus cholesterol equilibrates rapidly (half-time less than 1 h) between the two sides of the membrane

Topics: Research Article
Year: 1977
DOI identifier: 10.1042/bj1680575
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Provided by: PubMed Central
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