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Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp

By T Renton, Y Yiangou, C Plumpton, S Tate, C Bountra and P Anand

Abstract

BACKGROUND: The tetrodotoxin-resistant voltage-gated sodium channel Na(v)1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states. METHODS: Using specific antibodies for immunohistochemistry, we studied Na(v)1.8 – immunoreactivity in human dental pulp in relation to the neuronal marker neurofilament. Human tooth pulp was extracted from teeth harvested from a total of twenty-two patients (fourteen without dental pain, eight patients with dental pain). RESULTS: Fibres immunoreactive for Na(v)1.8, were significantly increased on image analysis in the painful group: median (range) Na(v)1.8 to Neurofilament % area ratio, non-painful 0.059 (0.006–0.24), painful 0.265 (0.13–0.5), P = 0.0019. CONCLUSION: Na(v)1.8 sodium channels may thus represent a therapeutic target in trigeminal nerve pain states

Topics: Research Article
Publisher: BioMed Central
Year: 2005
DOI identifier: 10.1186/1472-6831-5-5
OAI identifier: oai:pubmedcentral.nih.gov:1183220
Provided by: PubMed Central

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