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A Combined Linkage-Physical Map of the Human Genome

By X. Kong, K. Murphy, T. Raj, C. He, P. S. White and T. C. Matise

Abstract

We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N=14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers

Topics: Report
Publisher: The American Society of Human Genetics
Year: 2004
OAI identifier: oai:pubmedcentral.nih.gov:1182151
Provided by: PubMed Central
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