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Modulation by dexamethasone of the pyruvate dehydrogenase-complex activity in 3T3-L1 adipocytes.

By M S Patel, C Raefsky, C W Hu and L Ho

Abstract

Chronic exposure of 3T3-L1 pre-adipocytes to dexamethasone plus 3-isobutyl-1-methylxanthine (IBMX) with or without insulin caused a significant increase in the specific activity of 'total' pyruvate dehydrogenase complex (PDC) and in the percentage of the 'active' form of the complex compared with cells exposed to a chronic insulin treatment or an acute treatment (2 days) with dexamethasone plus IBMX. In acute-drug-switch-over experiments, dexamethasone also caused an increase in the percentage of 'active' PDC in 3T3-L1 adipocytes. The results show that, in 3T3-L1 adipocytes, dexamethasone, even in the absence of insulin, increases the proportion of PDC in its 'active' form. The mechanism of the dexamethasone effect remains to be investigated

Topics: Research Article
Year: 1985
DOI identifier: 10.1042/bj2260607
OAI identifier: oai:pubmedcentral.nih.gov:1144750
Provided by: PubMed Central
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