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Formation of bile pigments by coupled oxidation of cobalt-substituted haemoglobin and myoglobin.

By D I Vernon and S B Brown

Abstract

Treatment of cobalt-substituted haemoglobin and myoglobin with ascorbate and molecular O2 (coupled oxidation) resulted in biliverdin formation from the cobalt(II) derivatives but not from the cobalt(III) derivatives. This was apparently due to the inability of ascorbate to reduce cobalt(III) haemoproteins. Isomer analysis of the biliverdins produced from coupled oxidation of cobalt(II) oxyhaemoglobin suggested that the orientation of the cobalt protoporphyrin IX in the haem pocket differed slightly from that of the haem in native haemoglobin

Topics: Research Article
Year: 1984
DOI identifier: 10.1042/bj2230205
OAI identifier: oai:pubmedcentral.nih.gov:1144281
Provided by: PubMed Central
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