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Developmental regulation of the mRNAs for elastins a, b and c in foetal-calf nuchal ligament and aorta.

By R P Paulovic and R A Anwar

Abstract

The data presented clearly suggest that relative amounts of mRNAs for elastins a, b and c are developmentally regulated in foetal-calf nuchal ligament and aorta and that this regulation is tissue-specific. In nuchal ligament, at earlier stages of foetal development, the relative amounts of mRNAs for elastins a and b are very low. After the foetal age of about 6 months the relative amount of mRNA for elastin b begins to increase. This is followed by an increase in the relative amount of mRNA for elastin a. In aorta, with increasing foetal age, the relative amounts of mRNAs for elastins b and c increase and decrease alternately. The relative amounts of mRNA for elastin a remain low, with only marginal increases with foetal age. A possible self-aggregation role of elastin a in elastogenesis is proposed

Topics: Research Article
Year: 1989
DOI identifier: 10.1042/bj2610227
OAI identifier: oai:pubmedcentral.nih.gov:1138804
Provided by: PubMed Central
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