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Proinsulin and insulin responses to a mixed meal in hypertriglyceridaemic men.

By R Gama, F Norris, S Hampton, L Morgan, J Wright and V Marks

Abstract

AIM: To investigate the contribution of proinsulin to the "hyperinsulinaemia" of hypertriglyceridaemia. METHODS: Plasma glucose, triglyceride, immunoreactive insulin, and intact proinsulin concentrations were measured before and after a mixed meal in 11 hypertriglyceridaemic men and six healthy normotriglyceridaemic male controls. RESULTS: Hypertriglyceridaemic subjects had greater fasting (101 v 50 pmol/l) and integrated (139 v 81 x 0(-3) pmol/l/h) insulin concentrations than controls. Fasting and integrated glucose and proinsulin concentrations were similar in the two groups. CONCLUSIONS: Proinsulin does not contribute to the hyperinsulinaemia observed in hypertriglyceridaemic subjects and is therefore unlikely to contribute to the increased cardiovascular risk associated with hypertriglyceridaemia

Topics: Research Article
Year: 1999
DOI identifier: 10.1136/jcp.52.8.627
OAI identifier: oai:pubmedcentral.nih.gov:500958
Provided by: PubMed Central
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