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Chronic alcohol excess is associated with selective but reversible injury to type 2B muscle fibres.

By G Slavin, F Martin, P Ward, J Levi and T Peters


Patients drinking more than 100 g alcohol/day for longer than three years develop atrophy of striated muscle fibres. This predominantly affects type 2B fibres which are dependent on anaerobic glycolytic metabolism. Atrophy of type 1 and type 2A fibres, which in addition use aerobic mitochondrial respiration, only occurs in the most severe cases and then only to a lesser degree. Abstention from alcohol reverses the changes in muscle which slowly return to normal. Selective injury to type 2B fibres indicates that search should be made for an alcohol-induced biochemical lesion affecting the anaerobic glycolytic pathways of the muscle fibre

Topics: Research Article
Year: 1983
DOI identifier: 10.1136/jcp.36.7.772
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Provided by: PubMed Central
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