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Excision of the Shigella Resistance Locus Pathogenicity Island in Shigella flexneri Is Stimulated by a Member of a New Subgroup of Recombination Directionality Factors

By Shelley N. Luck, Sally A. Turner, Kumar Rajakumar, Ben Adler and Harry Sakellaris

Abstract

Pathogenicity islands are capable of excision and insertion within bacterial chromosomes. We describe a protein, Rox, that stimulates excision of the Shigella resistance locus pathogenicity island in Shigella flexneri. Sequence analysis suggests that Rox belongs to a new subfamily of recombination directionality factors, which includes proteins from P4, enterohemorrhagic Escherichia coli, and Yersinia pestis

Topics: Molecular Biology of Pathogens
Publisher: American Society for Microbiology
Year: 2004
DOI identifier: 10.1128/JB.186.16.5551-5554.2004
OAI identifier: oai:pubmedcentral.nih.gov:490928
Provided by: PubMed Central
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