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Deficiencies in anti-acetylcholine receptor antibody measurement in myasthenia gravis.

By C E Clarke, D I Shepherd, G M Yuill, J C Smaje and P B Wilson


In a retrospective case note study of 86 patients with myasthenia gravis, 60 had an anti-acetylcholine receptor antibody assay performed by the regional immunology laboratory. Antibody was detected in 38% which compares with 66-93% in other series. Whilst the use of staphylococcal protein A to precipitate the antibody-receptor complex, rather than anti-human immunoglobulin, may be partly responsible for this low sensitivity, other methodological problems are likely to exist. It is suggested that this potentially critical assay becomes a subject for regular audit

Topics: Research Article
Year: 1991
DOI identifier: 10.1136/jnnp.54.5.454
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Provided by: PubMed Central
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