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SOCS5 Is Expressed in Primary B and T Lymphoid Cells but Is Dispensable for Lymphocyte Production and Function

By Christine Brender, Ruth Columbus, Donald Metcalf, Emanuela Handman, Robyn Starr, Nick Huntington, David Tarlinton, Niels Ødum, Sandra E. Nicholson, Nicos A. Nicola, Douglas J. Hilton and Warren S. Alexander

Abstract

Suppressors of cytokine signaling (SOCSs) are key regulators of cytokine-induced responses in hematopoietic as well as nonhematopoietic cells. SOCS1 and SOCS3 have been shown to modulate T-cell responses, whereas the roles of other SOCS family members in the regulation of lymphocyte function are less clear. Here, we report the generation of mice with a targeted disruption of the Socs5 gene. Socs5(−/−) mice were born in a normal Mendelian ratio and were healthy and fertile. We found that SOCS5 is expressed in primary B and T cells in wild-type mice. However, no abnormalities in the lymphocyte compartment were seen in SOCS5-deficient mice. We examined antigen- and cytokine-induced proliferative responses in B and T cells in the absence of SOCS5 and found no deviations from the responses seen in wild-type cells. Because SOCS5 has been implicated in Th1 differentiation, we also investigated the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(−/−) mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears to be dispensable for the regulation of lymphocyte function

Topics: Mammalian Genetic Models with Minimal or Complex Phenotypes
Publisher: American Society for Microbiology
Year: 2004
DOI identifier: 10.1128/MCB.24.13.6094-6103.2004
OAI identifier: oai:pubmedcentral.nih.gov:480873
Provided by: PubMed Central
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