Article thumbnail
Location of Repository

Control of anticoagulant therapy: Postal comparison between five centres



Laboratory techniques used in the control of oral anticoagulant therapy were compared at five centres. The methods studied were: (a) prothrombin-proconvertin (`P and P') technique with the centres using their own reagents. This resulted in major discrepancies between the centres. (b) P and P technique with all the centres using centrally supplied reagents. The discrepancies noted under (a) disappeared when (b) was employed. (c) Thrombotest: the centres used the same batch of reagent and the specimens were transmitted in glass or polystyrene containers. The centres obtained closely comparable results, whether transportation was in glass or polystyrene. (d) Onestage `prothrombin' time with all the centres using the same reagents. When the results were read from a dilution curve there were discrepancies between the centres. For comparability of results between centres using anticoagulant therapy, centrally supplied P and P reagents or Thrombotest should be used. Since only the latter was commercially available as a centrally standardized reagent at the initiation of this trial, it emerged as the method of practical choice at the time

Topics: Articles
Year: 1964
OAI identifier:
Provided by: PubMed Central
Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full text.

Suggested articles

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.