Article thumbnail
Location of Repository

Steroid excretion and metabolism by gonadal tissue from a subject with testicular feminization syndrome

By E. Lockwood, P. C. Ghosh, G. W. Pennington and R. Tipton

Abstract

The initial clinical, pathological, and hormonal investigation of a patient with testicular feminization syndrome is described. Incubation of gonadal tissue with various radioactive substrates, together with the isolation and identification of the resulting metabolites, was demonstrated a high capacity to synthesize testosterone. Two biosynthetic pathways were demonstrated, originating from progesterone and pregnenolone. These are essentially similar to those of the normal adult testes. Low levels of activity were found in the phenolic fractions and no measurable production of oestrone, oestradiol, or oestriol was found

Topics: Articles
Year: 1974
DOI identifier: 10.1136/jcp.27.2.135
OAI identifier: oai:pubmedcentral.nih.gov:478027
Provided by: PubMed Central
Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full text.

Suggested articles


To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.