Article thumbnail
Location of Repository

Comparison of Gentamicin, Carbenicillin and Gentamicin, and Carbenicillin in Pseudomonas Sepsis in Monkeys

By Samuel Saslaw, Harold N. Carlisle and Mohammad Moheimani

Abstract

Intravenous inoculation of 6.0 × 10(10)Pseudomonas aeruginosa organisms into rhesus monkeys 4 days after intratracheal inoculation of 2.5 mg of vincristine sulfate resulted in fatal sepsis in all of three untreated control monkeys. After intramuscular administration of either 2.5 mg of gentamicin or 50 mg of carbenicillin per kg per day, three of four monkeys in each group survived. When both antibiotics were given at the same dose but in separate sites, six of eight monkeys survived. Antibacterial activity of serum from infected monkeys or normal monkeys was not appreciably different when the two antibiotics were combined. Under the conditions of this study, there was no apparent difference in response of monkeys treated either with gentamicin or carbenicillin alone or with the combination of the two antibiotics

Topics: Articles
Year: 1973
DOI identifier: 10.1128/aac.3.2.274
OAI identifier: oai:pubmedcentral.nih.gov:444400
Provided by: PubMed Central
Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full text.

Suggested articles


To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.