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rpoB Mutations in Streptococcus mitis Clinical Isolates Resistant to Rifampin

By Wafa Achour, Olfa Guenni, Marguerite Fines, Roland Leclercq and Assia Ben Hassen


Activity of rifampin against 129 Streptococcus mitis isolates obtained from patients with hematologic cancer was investigated. One hundred twenty-five strains were susceptible to rifampin, and 4 were resistant (MIC = 32 to 64 μg/ml). Resistance to rifampin was related to mutations in the rpoB gene: His(526)Asn in three strains and His(526)Asp in one strain

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology
Year: 2004
DOI identifier: 10.1128/AAC.48.7.2757-2759.2004
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Provided by: PubMed Central
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