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A Human Cellular Protein Activity (OF-1), Which Binds Herpes Simplex Virus Type 1 Origin, Contains the Ku70/Ku80 Heterodimer

By Lauren B. Murata, Mark S. Dodson and Jennifer D. Hall


In an effort to identify host proteins involved in herpes simplex virus type 1 replication, monkey and human cellular protein activities (called OF-1) that bind the viral replication origin, oriS, have been described. We show by mass spectrometry that the DNA-binding component of human OF-1 contains Ku70 and Ku80 proteins

Topics: Virus-Cell Interactions
Publisher: American Society for Microbiology
Year: 2004
DOI identifier: 10.1128/JVI.78.14.7839-7842.2004
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Provided by: PubMed Central
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