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Defective thymine dimer excision by cell-free extracts of xeroderma pigmentosum cells.

By K Mortelmans, E C Friedberg, H Slor, G Thomas and J E Cleaver

Abstract

Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet-irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell-free preparations of cells that had been labeled with [3H]thymidine. Extracts of xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell-free preparations

Topics: Research Article
Year: 1976
DOI identifier: 10.1073/pnas.73.8.2757
OAI identifier: oai:pubmedcentral.nih.gov:430730
Provided by: PubMed Central
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