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Comparative Pharmacology of Cefaclor and Cephalexin

By Oksana M. Korzeniowski, W. Michael Scheld and Merle A. Sande


Two cephalosporin antibiotics, cefaclor and cephalexin, were administered orally to healthy, adult male volunteers for comparison of their pharmacological properties. In doses of 250 mg orally, cefaclor produced a peak serum concentration of 6.01 ± 0.55 (standard deviation [SD]) μg/ml compared with 9.43 ± 2.36 μg/ml for cephalexin (P < 0.01). The half-lives were 0.58 ± 0.07 (SD) h and 0.80 ± 0.12 (SD) h, and elimination constants were 1.22 ± 0.15 and 0.88 ± 0.13 h(−1) for cefaclor and cephalexin, respectively (P < 0.001). Neither drug showed accumulation over the dosing period, and both were well tolerated

Topics: Pharmacology and Therapeutics
Year: 1977
DOI identifier: 10.1128/aac.12.2.157
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Provided by: PubMed Central
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